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September 3-6, 2017, Dublin, Ireland

Sunday 3 September
Parallel Tutorial Sessions
15:00 - 18:00Fundamentals of CrystallizationMonitoring & Control
18:30Welcome Reception
Monday 4 September
Theatre ATheatre BTheatre C
8:30 - 10:00Opening Session
8:30 - 8:40Opening Address
8:40 - 9:20Invited Plenary 1
9:20 - 9:4098 - From a single crystal to a crystal population: Measuring secondary nucleation rate through single crystal seeding.
M. L. Briuglia , J. H. ter Horst, and J. Sefcik
CMAC, University of Strathclyde, UK
9:40 - 10:0055 - Continuous manufacturing: Is the process mean stationary?
L.L. Simon
Illinois Institute of Technology, US
10:00 - 10:40 TEA/COFFEE BREAK
Theatre ATheatre BTheatre C
10:40 - 12:20Characterization & Monitoring (1)Fundamentals (1)Applications/Product Engineering (1)
10:40 - 11:00120 - Divergent Polymorphs and Solid-State Phase Transition of 4,4'-Bipyridine and Squaric Acid Salts
J. Stevens 1 , M. Walczak 1 , C. Jaye 2 , D. Fischer 2
1. Univ. Manchester, UK. 2. NIST, US
13 - Effect of Process Parameters on the Crystallization of Cholesterol Particles Using Liquid Antisolvent Process
S. Bachchlav , S. Roy , M. Mukhopadhyay
Indian Institute of Technology, INDIA
154 - Oiling-out crystallization of beta-alanine in binary solvent
M. Sun , J. Wang, J. Gong
Tianjin, CHINA
11:00 - 11:2056 - Water: the key factor both in the Jellylike Phase Formation and Crystallization of Cefquinome
L. Wang
Tianjin, CHINA
83 - Additive effects on the appearance and crystallisation kinetics of polymorphs of p-aminobenzoic acid
T. Vetter, R. Davey 1 , J. Black 1 , R. Willacy 2
1. University of Manchester, UK 2. GSK Medicines Research Centre, UK
62 - Crystallization-based isolation of a target compound from complex multicomponent mixtures originating from plant processing
H. Lorenz 1 , A. Seidel-Morgenstern 1,2 , P. Schulze 1 , E. Horosanskaia 2
1. Otto von Guericke University, GERMANY 2. MPI, GERMANY
11:20 - 11:40208 - Simultaneous measurement of the crystal size distribution and suspension flowability
H. Eloranta, M. Halaka, M. Honkanen
20 - Effect of Al3+ on Hydrothermal Formation of Calcium Sulfate Hemihydrate: A Combined Experimental and Molecular Dynamics Simulation Study
F. Hao, T. Lui, Y. Xu, X, Song, J. Yu
East China University of Science & Technology, CHINA
184 - Precipitation of fine API slurries via Ehrfeld® valve assisted micromixer: Impact of stabilizers on nucleation behavior and particle size (IPDO IPM-00468)
R. Susarla, I. Prashanth, S. Ramakrishnan
Dr Reddys, INDIA
11:40 - 12:00102 - Characterisation of hexadecane and octadecane binary system: revealed by XRD and DSC
X. Tang 1 , X. Lai 1 , K. Roberts 1 , P. Dowding 2 , I. More 2
1. Leeds, UK 2. Infineum UK Ltd
65 - Inhibition of mineral crystallization on seed surface and on heat exchange surface materials by using organic additives in conditions of industrial recirculating cooling circuits
N. Chhim 1,2 , T. Neveux 1 C. Bouteleux 1 , S. Teychene 2 , B. Biscans 2
1. EDF Lab, FRANCE 2. Université de Toulouse, FRANCE
39 - Diverse Applications of Rotor-Stator Wetmilling to Control API Attributes
A. Cote , A. Fine, I. Lee, E. Margelefsky, A. Moment, L. Schenck, E. Sirota
Merck, US
12:00 - 12:2086 - Tuning process parameters for the heterogeneous nucleation of active pharmaceutical ingredients on excipients
R. Arribas Bueno, C. Crowley, P. Davern, S. Hudson, K. Hodnett
219 - The Role of Impurity Induced Growth Defects in Crystal Habit Modification
X. Lai
Leeds, UK
45 - Development and Optimization of a Mixed Suspension Mixed Product Removal (MSMPR) Crystallization Process Incorporating Wet-milling
Y. Yang1 , C. Mitchell1, C. Papageorgiou1, N. Mitchell2, S. Bermingham2
1. Takeda, US 2. Process Systems Enterprise
12:20 - 13:30LUNCH
13:30 - 15:00POSTER SESSION 1
Theatre ATheatre BTheatre C
15:00 - 15:40Plenary 2
15:00 - 15:40Invited Plenary 2
15:40 - 16:0053 - Fine tuning of continuous crystallization of L-glutamic acid in an MSMPR-Tubular crystallizer series
S. Rohani1, Z. Gao12, Y. Wu1, J. Gong2, J. Wang2
1. Western University, CANADA 2. Tianjin University
16:00 - 16:20136 - The role of oiling out in crystallization
I. de Albuquerque , M. Mazzotti
Theatre ATheatre BTheatre C
16:50 - 18:10Design, scale-up, modelling & controlFundamentalsNovel directions/Industrial challenges
16:50 - 17:1068 - Manufacturing the stable polymorph in continuous crystallization - milling processes
T. Kollges , T. Vetter
Univ. of Manchester, UK
17 - Crystal Nucleation Rates of Organic Melt Droplets via a Microfluidic Crystallizer
B. Spiegel , A. Käfer, M. Kind
Karlsruhe Institute of Technology, GERMANY
131- Electric-Field-Enhanced Crystallization in Multi-component Mixtures
C. Moreno Leon2, W. Li 1, J. ter Horst2, H. Kramer1,
1. Technical University of Delft, NETHERLANDS 2. University of Strathclyde
17:10 - 17:3097 - Process synthesis of a continuous crystallization section for an ammonia-based CO2 capture process
F. Milella , D. Sutter, J. Pérez-Calvo, M. Gazzani, M. Mazzotti
42 - The Nucleation Kinetics of Aromatic Carboxylic Acids
Y. Xiao12 , T. Vetter2, S. Sachitananthan2, S. Tang2, R. Davey2, A. Cruz-Cabeza2, J. Wang1, H. Hao1
1. Tianjin University, CHINA 2. University of Manchester
202 - Investigating Grain Growth of Perovskite Films from One-Step and Two-Step Deposition Methods: Implications for Photovoltaic Application
A. Lewis 1, Y. Zhang2, P. Gao2, M. Nazeeruddin2
1. University of Capetown, SOUTH AFRICA 2. Ecole Polytechnique Federale de Lausanne
17:30 - 17:50140 - Continuous diastereomeric salt crystallization using ternary phase diagram: Ibuprofen lysine case study
M. Simon , R. Jones, P. Donnellan, B. Glennon
110 - Solvent and Composition Effects on Co-crystal Nucleation
O. Olalere , M. Briuglia, J. Sefcik, J. Ter Horst
University of Strathclyde, UK
180 - When purer does not mean better
E. Verdurand, M. Iggland, B. Zerrer
17:50 - 18:10123 - Continuous crystallization in a helically-coiled flow tube facilitates control over the crystal size and shape distribution
V. Wiedmeyer1 , A. Voigt1, K. Sundmacher12
1. Otto von Guericke University, GERMANY 2. MPI, GERMANY
105 - Examination of nucleation kinetics and mechanism of hexadecane and octadecane mixtures as a function of solution environment
D.M. Camacho Corzo1,X. Tang1, X. Lai1, P. Kaskiewicz1, K. Roberts1, P. Dowding2, I. More2
1. University of Leeds, UK 2. Infineum UK Ltd
19 - Functionalized nanoparticles for reversible control of crystallization and solubility
L. Dwyer, S. Kulkarni, L. Nicoud, A. Myerson
Tuesday 5 September
Theatre ATheatre BTheatre C
8:40 - 10:00Plenary 3
8:40 - 9:00144 - Preferential Crystallization of a Racemic Compound via its Conglomerate Co-crystal
J. ter Horst2, W. Li1, H. Kramer1, C. Moreno Leon2
1. Technical University of Delft, NETHERLANDS 2. University of Strathclyde
9:00 - 9:20209 - Impact of Scale-up and Dispersed Excipients on the Nucleation of Active Pharmaceutical Ingredients
V. Verma , R. Arribas-Bueno, C. Crowley, K. Hodnett, S. Hudson, P. Davern
9:20 - 10:00Invited Plenary 3
10:00 - 10:40Tea/Coffee
Theatre ATheatre BTheatre C
10:40 - 12:20Design, scale-up, modelling & control (2)Fundamentals (3)Novel directions/Industrial challenges (2)
10:40 - 11:00109 - The Potential of Size and Shape Feedback Control for Crystal Populations
S. Botschi 1, M. Morari2, M. Mazzotti1
1. ETH, SWITZERLAND 2. University of Pennsylvania
149 - Primary nucleation: statistical analysis and stochastic models
G. Maggioni, L. Bosetti, L. Bezinge, M. Benisch, E. dos Santos, M. Mazzotti
218 - Continuous Crystallization of Pharmaceuticals: State of the Art and Future Directions
S. Ferguson
11:00 - 11:2051 - Implementation of a Monte Carlo Population Balance Model in the Development of Pharmaceutical Batch Crystallizations
J. Tabora1, J. Sweeney1, N. Domagalski1, M. Mellmer1, R. Braatz2
1. BMS, US 2. Massachusetts Institute of Technology
134 - Coupling Small Angle X-ray Scattering and droplet microfluidics towards in-situ observation of pre-nucleation clusters
S. Teychené 1, D. Radajewski1, I. Rodríguez- Ruiz12, T. Bizien3, B. Biscans1, F. Bonneté4
1.Université de Toulouse 2. CEA,DEN,DMRC,SA2I 3. SWING beamlin 4. Université d’Avignon
78 - Continuous Crystallization and Transient Isolation of a GMP Intermediate
C. Polster, J. Groh, K. Cole, C. Burcham
Lilly, US
11:20 - 11:40126 - Case-study of an investigation of crystallization kinetics in a difficult system: dealing with fast kinetics
M. Iggland1, E. Verdurand1, H. Mumtaz2, N. Misailidis2
1. DSM, SWITZERLAND 2. Process Systems Enterprise
49 - Molecules as building blocks for a CFD-PBE model to describe the effect of fluid dynamics on nanoparticle formation
D. Marchisio1, A. Lavino1, N. Di Pasquale2, P. Carbone3
1. Politecnico di Torino 2. University of Leicester 3. University of Manchester
26 - Enhanced product quality control through a novel MSMPR cascade with separated zones of crystallization phenomena
M.C. Ostermann, M. Termühlen, S. Wibbeler, G. Schembecker, K. Wohlgemuth
Technical University of Dortmund, GERMANY
11:40 - 12:0050 - Dissolution Kinetics of a BCS Class II Active Pharmaceutical Ingredient using Population Balance Model
Y. Gao , P. Donnellan, Y. He, V. Kamaraju, G. Hou, B. Glennon
152 - Modification of calcium oxalate crystallization by tetrazoles
F. Jones, C. McMulkin, M. Massi
75 - Selective separation from solid side streams by crystallization at lower temperature
M. Hasan, M. John, M. Louhi-Kultanen
12:00 - 12:20158 - Growth and Nucleation Kinetics in Continuous Mixed-Solvent Crystallization Systems
J. Schall, J. Mandur, A. Myerson, B. Trout
196 - Morphological population balance modelling for simulating crystal size and shape evolution in pharmaceutical crystallisation processes
C. Ma, K. Roberts
Leeds, UK
168 - Prediction of Melting point of the Co-crystals prior to the Synthesis: ANN Models
R. Gamidi, M. Ukrainczyk, J. Zeglinski, A. Rasmuson
12:20 - 13:30LUNCH
13:30 - 15:00POSTER SESSION 2
Theatre ATheatre BTheatre C
15:00 - 15:50Design, scale-up, modelling & control (3)Fundamentals (4)Novel directions/Industrial challenges (3)
15:00 - 15:20151 - Development and evaluation of bench-scale cooling / freeze crystallization processes for recovery of itaconic acid from fermentation broth
M. Roelands1, C. Roa3, D. Verdoes2, I. Hernandez Mireles4, P. Koenst1, J. Urbanus1
1. TNO, 2. Soliqz, 3. Nutricia, 4. Jacobs
69 - Measurement and Modeling of the Phase Transformation between Carbamazepine Crystals and Carbamazepine:Nicotinamide (1:1) Cocrystals
A. Flood 1, T. Suwannikom1, N. Mitchell2
1. VIST, THAILAND 2. Process Systems Enterprise
130 - Simultaneous crystallization of potassium and sodium chloride from aqueous solution
F. Penha, M. Seckler
University of Sao Paulo, BRAZIL
15:20 - 15:3048 - Bridging from nano- to macroscale for crystal growth and dissolution prediction
E. Elts, M. Greiner, H. Briesen
Technical University Munich, GERMANY
167 - Organic crystal structure prediction –
From fundamental research to industrial application
M. Neumann
165 - Pressure-responsive, nanostructured fluids: new media for controlled antisolvent crystallization
N. Grimaldi, I. Rosbottom, D. Harbottle, B. Sylvain, J. Veciana, S. Sala, K. Roberts, A. Triolo, A. Brauer, N. Ventosa
15:30 - 15:5084 - Towards the Virtual Design of Experiments (vDoE) of a Cooling Crystallization Process via the Application of Population Balance Modelling
N. Mitchell 1, K. Girard2, P. Rose2, M. Birch2, B. Chekal2, S. Bermingham1
1. PSE, UK 2. Pfizer Inc.
213 - Polymorph Selection by Vapor Phase Deposition on Functionalized Substrates
M. Solomos, S. Swift
Georgetown University, US
47 - Crystallization of Photomechanical 4-cyano-4’-pentyloxy Azobenzene Crystals and their Reversible bending Mechanisms
H. Yunhui 1, H. Shuai2, G. Yanmei1, H. Hongxun1, Y. Haifeng2
1. Tianjin, CHINA 2. Peking, CHINA
15:50 - 16:20TEA/COFFEE
Theatre ATheatre BTheatre C
16:20 - 18:10Plenary 4
16:20 - 17:00Invited Plenary 4
17:00 - 17:20117 - Interferometry as a tool to determine the influence of whey salts on lactose crystallization
C. Choscz, C. Eder, H. Briesen
Tech Univ Munich, GERMANY
17:20 - 17:40 41 - Continuous crystallization to separate enantiomers exploiting two coupled fluidized bed crystallizers
A. Seidel-Morgenstern 1, E. Temmel 1 , K. Kerst 2 , D. Khlopov 1 , A. Bartz 1 , G. Janiga 2 , M. Mangold 3 , H. Lorenz 2
1. MPI, GERMANY 2. Otto von Guericke University, GERMANY 3. Technische Hochschule, GERMANY
17:40 - 18:10EFCE Award
19:30Conference Dinner
Wednesday 6 September
Theatre ATheatre BTheatre C
8:40 - 10:20Characterization & MonitoringDesign, scale-up, modelling & controlApplications/Product Engineering
8:40 - 9:00113 - Tubing microfluidic: from crystallization to X-ray diffraction
C. Gerard, S. Zhang, A. Ikni, G. Ferry, L. Vuillard, J. Boutin, L. Chavas, T.Huet, N. Ferte, R. Grossier, N. Candoni, S. Veesler
215 - Extending the design space of an anti-solvent and cooling crystallization process exhibiting a synergistic solubility to improve the physical properties of an API
M. Boukerche 1, W. Knabe2, N. Mitchell3
1. Lilly, US 2. Eurofins Lancaster 3. PSE
159 - Anti-solvent Crystallization of Tubular Vinpocetine and the Enhanced Dissolution in Aqueous Solution
P. Sun , J. Wang, J. Gong
Tianjin University
9:00 - 9:2095 - Real-time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-batch Stirred Crystallizer
B. Han, J. Puranen, M. Louhi-Kultanen
37 - Application of ultrasound waves for size-dependent particle separation for crystallization processes
E. Simone , M. Holmes, M. Povey
Leeds, UK
204 - API Particle Formation: Technological Approaches to Forming Unique API Characteristics
K. Donnelly, A. Przybyl, R. Wareham
9:20 - 9:4093 - Preparation, characterisation and crystallisation of chiral multi-component materials (MCMs): the case of naproxen and 2-aminopyridine
A. Cousen, A. Dunn, J. ter Horst, C. Wilson
Univ. of Bath, UK
182 - Application of mechanistic models for the online control of crystallization processes
Y. Salman 1, C. Ma1, J. Mack2, T. Mahmud1, N. Mitchell3, K. Roberts1
1. Leeds, 2. Perceptive Engineering Ltd, 3. PSE Ltd
100 - Enantioseparation of a chiral API by a combined preferential crystallization – selective dissolution process
E. Temmel, H. Buchholz, H. Lorenz, A. Seidel-Morgenstern
9:40 - 10:00139 - Development of Combined Continuous Reaction and Crystallization Process using PAT Tools
G. Pascaul, P. Donnellan, B. Glennon, R. Jones
194 - Modelling of precipitation in a continuous fluidized bed reactor with mechanical stirring
M. Bertrand 1, L. Mojica1, H. Muhr2, E. Plasari2, F. Auger3, A. Michaut3, M. Bertrand
163 - Crystallization in composite hydrogels for controlling polymorphism
M. Reus, H. Kramer, B. Eral
Technical University Delft, NETHERLANDS
10:00 - 10:2033 - Growth of Colloidal Particles during Sol-Gel Phase Transition of Resorcinol-Formaldehyde Solution under High Pressure
T. Yamamoto 1, M. Tayakout-Fayolle2, T. Kakibe1, H. Satone1, K. Iimura1, K. Itoh1, K. Maeda1
1. University Of Hyogo 2. Université Lyon
32 - Kinetic Modelling of an Industrial Crystallisation process
G. Taylor 1, N. Mitchell2
1. GSK 2. PSE
116 - Continuous Production of Fine Crystalline Particles by using Uniform Liquid-liquid Interface
H. Takiyama
Tokyo, JAPAN
10:20 - 10:50TEA/COFFEE
Theatre A
10:50 - 12:30Plenary 5
10:50 - 11:10166 - Crystal Transformation permits Deracemization of a Racemic Compound without Grinding
C. Xiouras 1, J. ter Horst2, T. Van Gerven1, G. Stefanidis1
1. Leuven, BELGIUM 2. University of Strathclyde
11:10 - 11:304 - Increase of production capacity using gassing crystallization
K. Wohlgemuth 2, R. Scheel2, G. Schembecker2, T. Kleetz1
1. Evonik Technology & Infrastructure Gmb 2. TU Dortmund University
11:30 - 12:10Invited Plenary 5
12:10 - 12:30Closing Address